Medicine For Regrowing Teeth To Be Tested On Humans For The First Time

A drug that could regrow teeth might hit the market by 2030, pending a successful clinical trial. Starting in September of this year, 30 adult males will receive the medicine intravenously as part of a Phase I study to assess its safety and effectiveness. This marks the first human trial for such a drug.

Previous animal testing showed promising results, with the formula demonstrating the ability to stimulate the regrowth of lost teeth. In ferrets, a single dose was sufficient to regrow a tooth. Researchers report that the drug was well-tolerated in these tests, with no adverse effects observed, paving the way for human trials.

The medication contains an antibody targeting the USAG-1 gene, which inhibits tooth growth by binding to a growth factor known as BMP. The initial phase of the trial will take place at Kyoto Hospital in Japan over 11 months, involving healthy individuals each missing at least one tooth.